Matrix Metalloproteinases Cleave Tissue Factor Pathway Inhibitor
نویسندگان
چکیده
منابع مشابه
Matrix metalloproteinases cleave tissue factor pathway inhibitor. Effects on coagulation.
The capacity of inflammatory cell-derived matrix metalloproteinases (MMPs) to cleave tissue factor pathway inhibitor (TFPI) and alter its activity was investigated. MMP-7 (matrilysin) rapidly cleaved TFPI to a major 35-kDa product. In contrast, MMP-1 (collagenase-1), MMP-9 (gelatinase B), and MMP-12 (macrophage elastase) cleaved TFPI into several fragments including the 35-kDa band. However, ra...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2000
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)61488-2